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Links to Resources About Long Covid and Severity in Children

Scientific Articles on Long Covid in Children and Young Adults

Dec 8 2020
Evidence of thrombotic microangiopathy in children with SARS-CoV-2 across the spectrum of clinical presentations…sC5b9 levels were abnormal even in children with minimal disease or an incidental finding of SARS-CoV-2 infection, suggesting that any exposure to SARS-CoV-2 may be sufficient to induce elevations in this biomarker:
https://ashpublications.org/bloodadvances/article/4/23/6051/474421/Evidence-of-thrombotic-microangiopathy-in-children

Jan 26 2021
Preprint, 129 children diagnosed with COVID-19 between March and November, 2020 were enrolled (mean age of 11 4.4 years, 62 (48.1%) female). Subsequently, three developed Multisystem Inflammatory Syndrome (2.3%) and two myocarditis (1.6%). Patients were assessed on average 162.5 ± 113.7 days after COVID-19 microbiological diagnosis. 41.8% completely recovered, 35.7% had 1 or 2 symptoms and 22.5% had 3 or more. 52.7% had at least one symptom 120 days or more after diagnosis:
https://www.medrxiv.org/content/10.1101/2021.01.23.21250375v1.full.pdf

Feb 18 2021
Multisystem inflammatory syndrome in children related to COVID-19: a systematic review:
https://link.springer.com/article/10.1007/s00431-021-03993-5

March 2021
Multiorgan impairment in low-risk individuals with post-COVID-19 syndrome: a prospective, community-based study shows 70% organ damage young people in 20s:
https://bmjopen.bmj.com/content/11/3/e048391

March 5 2021
In this study of 1695 patients 21 years or younger hospitalized for acute COVID-19 or multisystem inflammatory syndrome, 365 (22%) had neurologic involvement. Forty-three patients (12%) developed COVID-19–related life-threatening neurologic disorders, 11 (26%) died, and 17 (40%) survived with new neurologic sequelae:
https://jamanetwork.com/journals/jamaneurology/fullarticle/2777392

April 9 2021
Preliminary evidence of long covid in children, “Twenty out of 30 children (66.6%) assessed between 60 and 120 days after initial COVID-19 had at least one persisting symptom (13 had one or two symptoms, seven had three or more); 35 of 68 children (27.1%) had at least one symptom 120 days or more after diagnosis (21 had one or two symptoms, 14 had three or more). Twenty-nine out of the 68 (42.6%) children assessed ≥120 days from diagnosis were still distressed by these symptoms.”:
https://onlinelibrary.wiley.com/doi/10.1111/apa.15870

April 26 2021
A quarter of children experienced persistent symptoms months after hospitalization with acute covid-19 infection, with almost one in ten experiencing multi-system involvement:
https://www.medrxiv.org/content/10.1101/2021.04.26.21256110v1

May 8 2021
Long covid in children (subsides and mild by 8 weeks):
https://www.medrxiv.org/content/10.1101/2021.05.05.21256649v1.full.pdf

May 21 2021
Long covid, children Switzerland (June 30, 2021) “9% versus 10% reported at least one symptom beyond 4 weeks, and 4% versus 2% at least one symptom beyond 12 weeks.”:
https://www.medrxiv.org/content/10.1101/2021.05.16.21257255v2.full.pdf

June 8 2021
Pediatric long covid, “Our study shows that long-COVID is also present in the pediatric population. The main symptoms resemble those previously described in adults.“:
https://onlinelibrary.wiley.com/doi/10.1002/ppul.25521

June 23 2021
At 6 months, 61% (189/312) of all patients had persistent symptoms, which were independently associated with severity of initial illness, increased convalescent antibody titers and pre-existing chronic lung disease. We found that 52% (32/61) of home-isolated young adults, aged 16–30 years, had symptoms at 6 months, including loss of taste and/or smell (28%, 17/61), fatigue (21%, 13/61), dyspnea (13%, 8/61), impaired concentration (13%, 8/61) and memory problems (11%, 7/61):
https://www.nature.com/articles/s41591-021-01433-3

July 1 2021
Post MIS study, 6-month multidisciplinary follow-up and outcomes of patients with paediatric inflammatory multisystem syndrome (PIMS-TS) at a UK tertiary paediatric hospital: a retrospective cohort study:
https://www.thelancet.com/journals/lanchi/article/PIIS2352-4642(21)00138-3/fulltext

July 14 2021
Long covid and kids, “Estimates of how common long COVID is in children vary wildly”: https://www.nature.com/articles/d41586-021-01935-7h

July 14 2021
Neurological manifestations of SARS-CoV-2 infection in hospitalised children and adolescents in the UK: a prospective national cohort study: https://www.thelancet.com/journals/lanchi/article/PIIS2352-4642(21)00193-0/fulltext

July 29 2021
With emergence of newer variants of concern such as the Delta variant which caused the massive wave of Covid-19 in India, with varied presentations, Covid-19 Associated Hepatitis is one of them. Such new entities need to be timely identified and differentiated from other types of emerging syndromes in children for appropriate management:
https://www.medrxiv.org/content/10.1101/2021.07.23.21260716v1.full.pdf

July 31 2021
Evidence of lung perfusion defects and ongoing inflammation in an adolescent with post-acute sequelae of SARS-CoV-2 infection:
https://www.sciencedirect.com/science/article/pii/S2352464221001966

News Articles on Children with Long Covid

Dec 9 2020
Virtually all children infected with COVID-19 show signs of blood vessel damage, study shows:
https://www.studyfinds.org/children-with-covid-blood-vessel-damage/?amp&fbclid=IwAR2JcYherHns3lbsMzCcOj-m8tA1XFh-rIL72a2HSsVWxwfk1BBU3u9Sgvo
Also:
https://www.chop.edu/news/chop-researchers-find-elevated-biomarker-related-blood-vessel-damage-all-children-sars-cov-2

Dec 28 2020
We now know that children can absolutely get sick from Covid-19, that they can die from it, and that they can develop long-term health complications, even if their initial presentation seemed mild. And according to the Centers for Disease Control(CDC), “The number and rate of cases in children in the United States have been steadily increasing.”:
https://www.forbes.com/sites/leahcampbell/2021/12/28/the-importance-of-protecting-children-from-the-long-term-impacts-of-covid-19/?sh=625d97ba458e&fbclid=IwAR2bAA-5qia7Vb8JHQSWqC3uZjsyY1kACQ8daHqmA2tNdfp4FhU4EPrQ6M4

Feb 15 2021
Over 200 Children with Long covid in Stockholm:
https://www.svt.se/nyheter/lokalt/stockholm/allt-fler-barn-utreds-for-langtidscovid?fbclid=IwAR2jRijwtgnswZ5TR2XMm1uIsCAc0SjxA4ABY593xaVbsntbdo78tXNTB-w

Feb 16 2021
Post-COVID: ‘It is heartbreaking to watch your child suffer,’ Post-COVID strikes between 10% and 30% of children, many who had mild cases of the virus.:
https://www.jpost.com/israel-news/post-covid-pediatric-pandemic-heartbreaking-to-watch-your-child-suffer-659081

March 26 2021
German article, A study in which households with corona cases were followed over a longer period of time showed that five percent of children and adolescents under 14 years of age still had at least one symptom three months after an infection:
https://www.br.de/nachrichten/wissen/post-covid-mehr-corona-spaetfolgen-bei-kindern-und-jugendlichen,SSkm7A1

April 27 2021
Scientists interviewed the parents of more than 500 children who were admitted to a Moscow hospital with Covid between April and August last year. They found that a quarter had ongoing symptoms more than five months after returning home, with the most common ailments being fatigue, sleep disruption and sensory problems:
https://www.theguardian.com/world/2021/apr/27/children-may-be-at-risk-from-long-covid-symptoms-study-finds

July 15 2021
No more than a few hundred children in the U.S. have died from COVID-19 during the pandemic—compared with more than half a million deaths overall—but more than 4,000 have developed MIS-C, and we still don’t have foolproof ways to cure it: https://www.theatlantic.com/science/archive/2021/07/clues-about-mis-c-and-covid-19-kids/619447/

July 16 2021
Covid: Younger adults still at risk of serious organ damage – study:
https://www.bbc.com/news/health-57840825

Articles on Severity of Covid in Children

June 11 2021
Adolecents in hospital 2.5-3x flu:
https://www.cdc.gov/mmwr/volumes/70/wr/mm7023e1.htm?s_cid=mm7023e1_w

June 12 2021
Impact of covid on children USA:
https://www.medpagetoday.com/opinion/second-opinions/93055

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